The translation of biomedical knowledge to patients and users results in new medicines, medical technologies, and food products. This benefits our health, our environment, and economy. Animal testing is currently an important link in the biomedical development process, but it is increasingly under pressure. Often, animal tests are not a good model for human application; they are time-consuming, expensive, and cause animal suffering. To continue improving the health of humans and animals, a radically different approach is needed: making the step to humans and animals faster and more effective, without relying on animal testing by default.

The new Centre for Animal-Free Biomedical Translation (CPBT, in Dutch: Centrum voor Proefdiervrije Biomedische Translatie) will shape this approach, creating new business opportunities around animal-free technologies and biomedical translation. This allows the Netherlands to distinguish itself globally and realize its ambition of becoming a leader in animal-free innovation.

Aim

The CPBT is a national centre for valorizing and disseminating animal-free innovations and expertise. It aims to improve and accelerate the transition of new biomedical innovations to patients and users, at lower costs, and without the use of animals. This will lead to safer, more effective, and better medicines while reducing animal testing.

Together with a large number of national and international partners, the CPBT will work on the development and dissemination of animal-free biomedical innovations and expertise. The initial transition projects will focus on ALS, cystic fibrosis, osteoarthritis/rheumatic diseases, and asthma/COPD. The CPBT will implement the available and developed methods, tools, and expertise together with researchers and companies. The new centre will also offer education, training, advice, and support to enhance the acceptance and use of animal-free biomedical innovations. Combined, the CPBT will run an integrated program that accelerates the transition to animal-free testing and strengthens the Dutch economy.

Budget

The total budget available to the CPBT in the period from 2025 to 2034 is 245 million euros. 124.5 million of this budget is an investment from the Dutch National Growth Fund (NGF); the other funds are contributed by public and private CPBT partners.

The Centre at Utrecht Science Park

The CPBT will be established as a physical centre located at Utrecht Science Park, where expertise and infrastructure from leading Dutch knowledge institutions, research centres, and businesses come together to drive the transition to animal-free innovation. The CPBT will serve as a one-stop shop for organisations interested in adopting animal-free biomedical translation or for those looking to conduct preclinical research in the most efficient way. Our approach is built on four interconnected components explained below, forming a comprehensive strategy to enhance biomedical research and translation. The centre will leverage the knowledge and tools developed through its transition projects, transforming them into marketable propositions and spin-outs, supported by in-house expertise.

How the CPBT operates

Transition Projects: Within the CPBT's transition projects, public and private partners will collaborate to develop new tools, methods, and knowledge to demonstrate the transition to animal-free biomedical translation in light of current biomedical challenges. The initial transition projects focus on ALS, Cystic Fibrosis, Osteoarthritis & Rheumatoid Arthritis, and Asthma & COPD.

Expertise Development: Alongside the transition projects, the CPBT will implement an in-house advanced development program. This program will expand the knowledge acquired from the transition projects and cultivate new expertise, thereby strengthening each proposition and addressing existing challenges and hurdles. The CPBT's efforts will concentrate on four key areas:

1. Transition science, ethics, and sustainability
2. Regulatory innovation
3. Educational program development
4. Data science, supporting tools and models

Propositions: The methods, tools, and expertise developed within the transition projects are used to create propositions for academic researchers, companies, and governmental bodies. The CPBT will provide the following propositions:

1. Training and education on animal-free biomedical translation
2. Advising on existing data, tools and methods for animal-free biomedical translation
3. Providing support for the validation and adoption of animal-free tools and models
4. Supporting the development of new animal-free methods, tools, and models.

Spin-out Activities: The CPBT will support spin-outs emerging from the new products, methods, tools, expertise, and services developed within its transition projects. This support will include mobilising financing, drafting business plans, building strong teams, and integrating these spin-outs into the thriving animal-free innovation ecosystem.